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Contraindicated (1)pentobarbital will lower the extent or outcome of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.Check Closely (one)pentobarbital will reduce the extent or result of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Loss of, or decreased response to tofacit